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KMID : 0043320080310040490
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Archives of Pharmacal Research
2008 Volume.31 No. 4 p.490 ~ p.496
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Comparison of Suppressive Effects of Demethoxycurcumin and Bisdemethoxycurcumin on Expressions of Inflammatory Mediators In Vitro and In Vivo
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Guo Lian Yu
Shin Eun-Myoung
Kim Yeong-Shik
Lee Jung-Joon
Kang Sam-Sik
Cai Xing Fu
Zhou Hong-Yu
Jung Ji-Won
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Abstract
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Demethoxycurcumin and bisdemethoxycurcumin are the main active ingredients isolated from Curcumae Longae Radix. Recent studies demonstrated that both compounds exhibit antioxidative and anti-inflammatory effects as well as effects on cancer cell lines. In this study, we compared the activities of demethoxycurcumin and bisdemethoxycurcumin, and both compounds were evaluated on lipopolysaccharide (LPS)-induced nitric oxide (NO) production, inducible nitric oxide synthase (iNOS), cycloxygenase-2 (COX-2) and nuclear factor-kappaB activity in a RAW 264.7 macrophage cell line. The evaluation:results suggested that the anti-inflammatory properties of demethoxycurcumin and bisdemethoxycurcumin were attributed to the inhibition of iNOS and COX-2 expression, as initiated by the inhibition of activity. Additionally, both of them significantly inhibited carrageenan-induced paw edema in mice. Taken together, all of the results showed that the suppressive effect of demethoxycurcumin was stronger than that of bisdemethoxycurcumin, indicating that the methoxy group had enhanced demethoxycurcumin’s anti-inflammation effects.
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KEYWORD
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Demethoxycurcumin, Bisdemethoxycurcumin, LPS, Macrophage, Paw edema
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